DNA demethylation by DNA repair
نویسندگان
چکیده
منابع مشابه
DNA demethylation by DNA repair.
Active DNA demethylation underlies key facets of reproduction in flowering plants and mammals and serves a general genome housekeeping function in plants. A family of 5-methylcytosine DNA glycosylases catalyzes plant demethylation via the well-known DNA base-excision-repair process. Although the existence of active demethylation has been known for a longer time in mammals, the means of achievin...
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Gemcitabine is a cytotoxic cytidine analog, which is widely used in anti-cancer therapy. One mechanism by which gemcitabine acts is by inhibiting nucleotide excision repair (NER). Recently NER was implicated in Gadd45 mediated DNA demethylation and epigenetic gene activation. Here we analyzed the effect of gemcitabine on DNA demethylation. We find that gemcitabine inhibits specifically Gadd45a ...
متن کاملActive DNA demethylation mediated by DNA glycosylases.
Active DNA demethylation is involved in many vital developmental and physiological processes of plants and animals. Recent genetic and biochemical studies in Arabidopsis have demonstrated that a subfamily of DNA glycosylases function to promote DNA demethylation through a base excision-repair pathway. These specialized bifunctional DNA glycosylases remove the 5-methylcytosine base and then clea...
متن کاملDna Demethylation by Dna Repair Accessed Terms of Use Detailed Terms
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متن کاملThymine DNA Glycosylase Is Essential for Active DNA Demethylation by Linked Deamination-Base Excision Repair
DNA methylation is a major epigenetic mechanism for gene silencing. Whereas methyltransferases mediate cytosine methylation, it is less clear how unmethylated regions in mammalian genomes are protected from de novo methylation and whether an active demethylating activity is involved. Here, we show that either knockout or catalytic inactivation of the DNA repair enzyme thymine DNA glycosylase (T...
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ژورنال
عنوان ژورنال: Trends in Genetics
سال: 2009
ISSN: 0168-9525
DOI: 10.1016/j.tig.2008.12.001